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ea0033oc1.4 | Oral Communications 1 | BSPED2013

Abnormal glucose homeostasis in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation is associated with reduced β-cell reserve and pancreatic volume

Wei Christina , Thyagiarajan Manigandan , Hunt Linda , Bradley Karin , Elson Ruth , Cox Rachel , Stevens Michael , Crowne Elizabeth

Background: Adult survivors of childhood acute lymphoblastic leukaemia (ALL) treated with bone marrow transplantation (BMT) and total body irradiation (TBI) have increased risk of impaired glucose tolerance (IGT) and diabetes mellitus (DM). Insulin resistance (IR) has been described, but effects of TBI on pancreatic growth and β-cell function have not been previously reported.Method: Two groups of childhood ALL survivors were studied: Group 1, treat...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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